Keynote Speaker 3 : Assoc. Prof. Dr. Azrul Azlan bin Hamzah
Senior Research Fellow, Institute of Microengineering and Nanoelectronics (IMEN),
Institute of Microengineering and Nanoelectronics (IMEN),
Universiti Kebangsaan Malaysia, UKM
43600, Bangi, Selangor.
Development of anti-diuretic hormone (ADH) Sensor for Smart Monitoring of Fluid Level in Artificial Kidney
Nephrogenic diabetes insipidus (NDI), which can be congenital or acquired, results from failure of the kidney to respond to Antidiuretic Hormone (ADH). This disorder leads to excessive urine production. Reliable biosensor is required to overcome this phenomena in order to regulate amount of urine production, particularly in artificial kidney. One of the most prominent biosensor is graphene based field effect transistor (FET) sensors. Graphene is a nanomaterial consisting of a monolayer of carbon atoms arranged in two-dimensional hexagonal crystalline form. The monoatomic structure of graphene offers unique properties
such as high mechanical strength, distinctive electronic properties, high carrier mobility, high saturation velocity, and low charge scattering. Owing to these properties graphene has been used in sensitive detection of analytes. In particular, conductance based Field Effect Transistor (FET) graphene biosensor have received much attention because of their simple design and ability to allow sensitive measurements. This research is to be conducted to finding ways to fabricate graphene based field effect transistor (G-FET) using cost effective
materials and methods for effective detection of Antidiuretic Hormone (ADH). As a first step, G-FET will be modelled and simulated using Lumerical DEVICE software in order to study and optimize parameters involved. Then, these optimized parameters will be used in effective fabrication of graphene based field emission transistor (G-FET). Then, fabricated structures will be functionalized with aptamers to detect concentration of ADH hormones produced by pituitary glands. Finally, functionalized biosensor will be integrated with microfluidic device to regulate the amount of urine produced by artificial kidney. In short, this field is new emerging field and it is capable of producing low cost and highly effective chemical sensors. The sensor would then provides data for smart and remote monitoring of patient's real-time fluid level, directly from doctor's office.
1. Ph.D. (Microelectromechanical Systems), Universiti Kebangsaan Malaysia, Bangi, 2008.
2. BSc. (Manufacturing Engineering), University of California, Berkeley, USA, May 2000.
1. MEMS for Micro Energy Generation and the Environment
2. Silicon Nanofilter for Water Purification in Limited Resource Areas
3. MEMS Microgenerator and Storing Unit for Powering Biomedical Implants
4. Development of High Temperature Resistant Silicon Carbide (SiC) based MEMS Pressure Sensor for Monitoring Gas Turbine Performance
6. Thin Nanoporous Silicon Membrane for Biological Fluids Filtration
Some selected publications
Chapter in Book
1. Azrul Azlan Hamzah, Dee Chang Fu, Suraya Sulaiman, Burhanuddin Yeop Majlis and Ibrahim Ahmad, SU-8 and AZ P4620 as Structural Material for Micro-Actuator, in MEMS Technology and Devices, eds. Aiqun Liu, Jiuhui Wu, Chun Lu, Chilla Damodara Reddy, Pan Stanford Publishing (2007).
1. Azrul Azlan Hamzah, Burhanuddin Yeop Majlis and Ibrahim Ahmad, HF etching of sacrificial spin-on glass in straight and junctioned microchannels for MEMS microstructures release, J. Electrochem. Soc., Volume 154, Issue 8, pp.D376-D382 (2007) (Q1).
2. Azrul Azlan Hamzah, Yusnira Husaini, Burhanuddin Yeop Majlis and Ibrahim Ahmad, Selection of high strength encapsulant for MEMS devices undergoing high pressure packaging, Microsyst. Technol., 14(6), pp. 761-766 (2007).
3. Azrul Azlan Hamzah, Jumril Yunas, Burhanuddin Yeop Majlis and Ibrahim Ahmad, Sputtered encapsulation as wafer level packaging for isolatable MEMS devices: A technique demonstrated on a capacitive accelerometer, Sensors, 8(11), pp. 7438-7452 (2008) (Q1).
4. Jumril Yunas, Azrul Azlan Hamzah and Burhanuddin Yeop Majlis, High-frequency analysis on surface micromachined on-chip transformers with stacked interwinding coil structures, J. Micromechanics and Microengineering 18(12), art. No. 125009 (2008) (Q1).
5. Azrul Azlan Hamzah, Jumril Yunas, Dee Chang Fu, Burhanuddin Yeop Majlis and Ibrahim Ahmad, Encapsulation fabrication techniques for MEMS devices: An overview of current technologies, Jurnal Elektronika dan Telekomunikasi 9(2), pp. 154-162 (2009).
6. Jumril Yunas, Azrul Azlan Hamzah and Burhanuddin Yeop Majlis, Fabrication and characterization of surface micromachined stacked transformer on glass substrate, Microelect. Engineering 86(10), pp. 2020-2025 (2009).
7. Jumril Yunas, Azrul Azlan Hamzah and Burhanuddin Yeop Majlis, Surface micromachined on-chip transformer fabricated on glass substrate, Microsyst. Technol. 15(4), pp. 547-552 (2009).
8. Dee, C.F., Lee, J.D., Sow, C.H., Majlis, B.Y., Hamzah, A., Abdullah, H. and Lee, S.-K., Simulation for deposition of ZnO thin film layer by kinetic Monte Carlo method, Material Research Innovations 13(3), pp. 135-138(4) (2009).
9. Jumril Yunas, Azrul Azlan Hamzah and Burhanuddin Yeop Majlis, Improved fabrication technique of stack sandwich micro-transformers, Jurnal Elektronika dan Telekomunikasi 9(2), pp. 174-179 (2009).
10. Yusnira Husaini, Azrul Azlan Hamzah, Mohd Nor Fadli Abu Kassim and Burhanuddin Yeop Majlis, Carbon fiber encapsulation for packaging biomedical lab-on-chip components, World Applied Sciences Journal 10(5), pp. 489-493 (2010).
11. Jumril Yunas, Juliana Johari, Azrul Azlan Hamzah, Mimiwaty, Ille C. Gebeshuber, and Burhanuddin Yeop Majlis, Design and fabrication of MEMS micropumps using double sided etching, Journal of Microelectronics and Electronic Packaging 7(1), pp. 44-47 (2010).
12. J. Yunas, N. Sulaiman, G. Sugandi, Azrul Azlan Hamzah, B. Y. Majlis Geometrical analysis of planar coil design for fluxgate magnetometer, Microsystem Technologies 16(11), pp. 1939-1944 (2010).